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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2C
All Species:
13.64
Human Site:
Y461
Identified Species:
25
UniProt:
P25092
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25092
NP_004954.2
1073
123369
Y461
L
R
K
Y
R
K
D
Y
E
L
R
Q
K
K
W
Chimpanzee
Pan troglodytes
XP_528746
1073
123536
Y461
L
R
K
Y
K
K
D
Y
E
L
R
Q
K
K
W
Rhesus Macaque
Macaca mulatta
XP_001089601
1073
123492
Y461
L
R
K
Y
K
K
D
Y
E
L
R
Q
K
K
W
Dog
Lupus familis
XP_543798
1072
122882
Y459
L
R
K
Y
K
K
E
Y
E
L
R
Q
K
K
W
Cat
Felis silvestris
Mouse
Mus musculus
Q3UWA6
1072
123214
H461
L
R
K
Y
R
R
D
H
A
L
R
Q
K
K
W
Rat
Rattus norvegicus
P23897
1072
123448
H460
L
R
K
Y
R
R
D
H
E
L
R
Q
K
K
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520217
1075
122497
H462
I
W
K
Y
R
R
D
H
E
L
R
Q
K
K
W
Chicken
Gallus gallus
XP_416207
1070
123254
N458
L
R
K
Y
R
R
D
N
E
R
R
R
K
K
W
Frog
Xenopus laevis
NP_001079334
1065
122503
N454
F
R
R
Y
R
L
E
N
E
L
R
Q
K
K
W
Zebra Danio
Brachydanio rerio
XP_700803
484
55110
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
E495
L
I
K
H
Y
R
Y
E
Q
T
L
A
G
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
I519
I
I
G
C
L
C
V
I
S
G
K
R
A
E
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
R462
Y
P
I
G
T
F
N
R
E
N
G
Q
W
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.5
87.7
N.A.
81.8
82.4
N.A.
73.5
67.7
62.4
31.4
N.A.
27.9
N.A.
24.8
28.6
Protein Similarity:
100
99.5
98.7
93.5
N.A.
90.1
90.7
N.A.
83.7
80.6
77
37.3
N.A.
45.2
N.A.
45.2
46.3
P-Site Identity:
100
93.3
93.3
86.6
N.A.
80
86.6
N.A.
73.3
73.3
66.6
0
N.A.
13.3
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
93.3
86.6
80
0
N.A.
33.3
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
0
8
8
0
0
% A
% Cys:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
54
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
16
8
70
0
0
0
0
8
0
% E
% Phe:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
8
8
0
0
0
0
0
8
8
0
8
8
0
% G
% His:
0
0
0
8
0
0
0
24
0
0
0
0
0
0
0
% H
% Ile:
16
16
8
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
70
0
24
31
0
0
0
0
8
0
70
70
0
% K
% Leu:
62
0
0
0
8
8
0
0
0
62
8
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
16
0
8
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
70
0
0
0
% Q
% Arg:
0
62
8
0
47
39
0
8
0
8
70
16
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
70
% W
% Tyr:
8
0
0
70
8
0
8
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _